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KMID : 0350519960490041305
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Journal of Catholic Medical College
1996 Volume.49 No. 4 p.1305 ~ p.1322
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The Effect of Hyperoxia and Antenatal Propylthiouracil Administration on the Activity of
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Abstract
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The antioxidant enzyme system keeps lung function and structure normally by scavenging oxygen free radicals which was produced during cell metabolism. During exposure of mammals to hyperoxia, the generation of oxygen radicals are increased in the
lungs
and resulting in pulmonary inflammation through peroxidation of lipid of cell membrane. For the last 10-15% of gestational period, rapid development of fetal lung differentiation in association with maturation of surfactant system and antioxidant
system
can protect newborn from acute changes in oxygen environment. It is still unclear whether these maturation process shown in normal fetus are accelerated or depressed in the fetus of intrauterine growth retardation. Propylthiouracil, originally
known as
antithyroid drug, has been proved its antioxidant effect in newborn rats of normal intrauterine growth, when administered antenatally to pregnant rats. But, the exact mechanism of antioxidant effects of propylthiouracil is not clear until now.
And
also
the effects of propylthiouracil on newborn rats of intrauterine growth retardation have not been reported yet.
@ES The results were as follows;
@EN 1. The survival rate was significantly lower in IUGR group than in control group (P<0.001).
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